A Case of Acute Eosinophilic Pneumonia after Hematopoietic Stem Cell Transplantation.

Tuberculosis and Respiratory Diseases

article

Park, Hwan Sung¹  Ok, Tae Jin¹  Kim, You Jae¹  Kim, Guang Un¹  Park, Soeun¹  An, Jihyun¹  Kim, Yun Ku¹  Jeong, Jae Ho¹  Kim, Su Jeong¹  Lee, Yumi¹  Lee, Ho Su¹  Kang, Bo Hyoung¹  Kim, Ga Hee¹  Kim, Dae Young²  Kim, Woo Sung³  Kim, Dong Soon³  Song, Jin Woo³ 

[1] Departments of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine;Departments of Hematology, Asan Medical Center, University of Ulsan College of Medicine;Departments of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine

关键词: Pulmonary Eosinophilia;    Hematopoietic Stem Cell Transplantation;    Graft vs Host Disease;   

DOI  :  10.4046/trd.2011.71.6.459

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

Pulmonary complications occur in 40~60% of patients who receive hematopoietic stem cell transplantation (HSCT) and are a source of substantial morbidity and mortality. Acute eosinophilic pneumonia (AEP) is an uncommon, non-infectious pulmonary complication occurring in HSCT recipients. We now report the case of a 52-year-old man with AEP who was treated with allogenic HSCT due to acute myeloid leukemia. He complained of fever, cough and dyspnea 390 days after allogenic HSCT. He also had skin and hepatic graft versus host disease (GVHD). Hypoxemia, diffuse pulmonary infiltrates on a chest x-ray and eosinophilia in bronchoalveolar lavage fluid were also noted in several tests. His symptoms, pulmonary infiltrates, hepatic dysfunction and skin lesions rapidly improved after treatment with corticosteroid therapy. Our case supports the idea that AEP is a late phase non-infectious pulmonary complication and one of the manifestations of chronic GVHD.

【 授权许可】

CC BY-NC