Recent 10 Years' Trend Analysis of Inhaled Corticosteroids Prescription Rate and Severe Exacerbation Rate in Asthma Patients.

Tuberculosis and Respiratory Diseases

article

Noh, Chang Suk¹  Lee, Jae Seung¹  Song, Jin Woo¹  Kim, Tae Bum³  Kim, Nam Kug⁴  Cho, You Sook³  Lee, Sang Do¹  Moon, Hee Bom³  Oh, Yeon Mok¹ 

[1] Departments of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine;Departments of Asthma Center, Asan Medical Center, University of Ulsan College of Medicine;Departments of Allergy and Clinical Immunology, University of Ulsan College of Medicine;Departments of Radiology Asan Medical Center, University of Ulsan College of Medicine

关键词: Asthma;    Disease Exacerbation;    Inhalers;    corticosteroid;   

DOI  :  10.4046/trd.2011.70.5.416

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

BACKGROUND Inhaled corticosteroids (ICSs) are the most essential medication for asthma control. Many reports suggest that the usage of ICSs improves not only the control of asthma symptoms but also prevents exacerbation. We investigated whether increases in ICS prescriptions are associated with decreases in asthma exacerbation in the clinical practice setting. METHODS: We retrospectively analyzed the database of adult asthma patients who had visited a tertiary referral hospital, the Asan Medical Center between January 2000 and December 2009. The number of emergency department (ED) visits, admissions, intensive care unit (ICU) care, deaths, and ICS prescriptions were analyzed to evaluate the time trend of asthma exacerbation as a function of the ICS prescription rate during the ten years. RESULTS: The numbers of ED visits, admissions, and episodes of ICU care decreased during the ten years (p<0.001, p=0.033, p=0.001, respectively) while the number of ICS prescriptions increased (p<0.001). We found a correlation between the number of ICS prescriptions and the number of ED visits, admissions, or ICU care. For these outcomes, the correlation coefficients were r=-0.952, p<0.001; r=-0.673, p=0.033; r=-0.948, p<0.001, respectively. CONCLUSION: The number of ICS prescriptions increased during the past ten years while the number of asthma exacerbations decreased. Our results also showed a negative correlation between the ICS prescription rate and asthma exacerbation in the clinical practice setting. In other words, an increase in ICS prescription may be a major cause of a decrease in asthma exacerbations.

【 授权许可】

CC BY-NC