Cell Differentiation Might Predict the Recurrence in Surgically Resected Non-Small Cell Lung Carcinoma.

Tuberculosis and Respiratory Diseases

article

Kang, Hyung Koo¹  Cho, Sung Gun¹  Lee, Hye Min¹  Park, Sung Woon¹  Lee, Byung Ook¹  Lee, Jae Hee¹  Kim, Bo Min¹  Park, In Won¹ 

[1] Division of Respiratory and Allergy Medicine, Department of Internal Medicine, Chung-Ang University College of Medicine

关键词: Carcinoma;    Non-Small-Cell Lung;    Recurrence;    Risk Factors;    Cell Differentiation;   

DOI  :  10.4046/trd.2010.68.1.10

学科分类：医学（综合）

来源: The Korean Academy of Tuberculosis and Respiratory Diseases

【 摘 要 】

BACKGROUND Lung cancer is the most common cause of cancer mortality in Korea. The TNM stage at presentation in patients with non-small cell lung cancer (NSCLC) has the greatest impact on prognosis. Patients who undergo a complete resection for NSCLC are likely to develop recurrent and/or metastatic disease. There are several factors influencing the development of recurrence. We explored risk factors of recurrence in patients with stages I and II NSCLC, who had undergone curative resection. METHODS: We reviewed patients who had complete surgical resection as definitive treatment for stage I or II. Patients followed up for more than 36 months. We evaluated several factors which might have relationship with recurrence, such as patient's demographic factors, TNM staging, pathologic finding, tumor markers and surgical technique. RESULTS: A total of 75 patients were enrolled for analysis, of whom 58 were men and 17 were women with mean age of 61 (range, 37 to 76) years. The average size of tumors was 3.9 cm (0.7 to 10 cm). There were 64 patients with stage I NSCLC and 11 with stage II NSCLC. Among 64 patients with stage I NSCLC, 35 patients showed recurrences whereas 8 patients have recurred in stage II NSCLC. Grade of differentiation of tumor was closely related to the recurrence. Seventy-five percent of patients who had poor tumor differentiation experienced a recurrence. In contrast, 3 patients of twelve had recurrences, who revealed differentiation in their tissue (p<0.05). CONCLUSION: Tumor differentiation could be a predictive factor for tumor recurrence in patients who have undergone curative resection for stage I or II NSCLC.

【 授权许可】

CC BY-NC