The Functional & Quality of Life Outcomes of Total Glossectomy with Laryngeal Preservation

Laryngoscope Investigative Otolaryngology

article

Justin M. Pyne¹  Peter T. Dziegielewski²  Gabriela Constantinescu³  Agnieszka Dzioba¹  Daniel A. O'Connell¹  David W. J. Côté¹  Khalid Ansari¹  Jeffrey Harris¹  Dustin Conrad¹  Fawaz M. Makki¹  Matthew Hearn¹  Vincent L. Biron¹  Hadi Seikaly¹ 

[1] Department of Surgery, Division of Otolaryngology – Head and Neck Surgery, University of Alberta;Department of Otolaryngology, University of Florida;Institute for Reconstructive Sciences in Medicine, Caritas Health Group;Communication Sciences and Disorders, University of Alberta;Department of Otolaryngology Head & Neck Surgery, King Faisal Specialist Hospital & Research Center

关键词: anterolateral thigh free-flap;    free-flap;    functional outcomes;    larynx preservation;    oral cancer;    quality of life;    total glossectomy;   

DOI  :  10.1002/lio2.435

学科分类：环境科学（综合）

来源: Wiley

【 摘 要 】

Background: The tongue is an essential organ for human interaction, communication and survival. To date, there is a paucity of objective functional, patient reported, or quality of life outcomes of patients undergoing a total glossectomy with preservation of the larynx (TGLP). Objective: To examine prospectively collected objective, self-reported functional and quality of life (QOL) data in patients undergoing TGLP and free flap reconstruction. Methods: Sixteen TGLP patients were identified in the prospective head and neck cancer and functional outcomes database between January of 2009 and December 2017. Data collection included patient age, sex, performance status, TNM staging, diagnosis and adjuvant treatment. Swallowing and speech functions were measured and prospectively recorded pre- and postoperatively. Patient reported outcomes were measured with the Speech Handicap Index (SHI) and the M.D. Anderson Dysphagia Inventory (MDADI). Results: All patients had a significant reduction in their objective swallowing (P = 0.035), sentence (P = 0.001) and word intelligibility (P < .001) scores. There was no significant reduction in SHI or total MDADI scores. All patients maintained their QOL in the post-treatment time frame. There was no relationship between free-flap type and outcome. Conclusion: Total glossectomy with laryngeal sparing and free flap reconstruction results in significant reduction in objective functional measurements, but patients report stable functional and quality of life outcomes after treatment.

【 授权许可】

CC BY|CC BY-NC-ND