Transgelin-2 in immunity: Its implication in cell therapy

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Suin Jo¹  Hye-Ran Kim¹  YeVin Mun¹  Chang-Duk Jun¹ 

[1] School of Life Sciences, Gwangju Institute of Science and Technology;Immune Synapse and Cell Therapy Research Center, Gwangju Institute of Science and Technology

关键词: actin-binding protein;    B lymphocytes;    immunological synapse;    immunotherapy;    macrophages;    T lymphocytes;    transgelin-2;   

DOI  :  10.1002/JLB.MR1117-470R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Transgelin-2 is a small 22-kDa actin-binding protein implicated in actin dynamics, which stabilizes actin structures and participates in actin-associated signaling pathways. Much curiosity regarding transgelin-2 has centered around its dysregulation in tumor development and associated diseases. However, recent studies have shed new light on the functions of transgelin-2, the only transgelin family member present in leukocytes, in the context of various immune responses. In this review, we outlined the biochemical properties of transgelin-2 and its physiological functions in T cells, B cells, and macrophages. Transgelin-2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse. Transgelin-2 in B cells also participates in the stabilization of T cell–B cell conjugates. While transgelin-2 is expressed at trace levels in macrophages, its expression is highly upregulated upon lipopolysaccharide stimulation and plays an essential role in macrophage phagocytosis. Since transgelin-2 increases T cell adhesion to target cells via boosting the "inside-out" costimulatory activation of leukocyte function-associated antigen 1, transgelin-2 could be a suitable candidate to potentiate the antitumor response of cytotoxic T cells by compensating for the lack of costimulation in tumor microenvironment. We discussed the feasibility of using native or engineered transgelin-2 as a synergistic molecule in cell-based immunotherapies, without inducing off-target disturbance in actin dynamics in other cells.

【 授权许可】

CC BY