New revelations from an old receptor: Immunoregulatory functions of the inhibitory Fc gamma receptor, FcγRIIB (CD32B)

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Ali Roghanian¹  Richard J. Stopforth¹  Lekh N. Dahal¹  Mark S. Cragg¹ 

[1] Antibody and Vaccine Group, Centre for Cancer Immunology, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital;Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology

关键词: Fc gamma receptor;    IgG;    immunotherapy;    B lymphocytes;    myeloid;    antibodies;   

DOI  :  10.1002/JLB.2MIR0917-354R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

The Fc gamma receptor IIB (Fc?RIIB/CD32B) was generated million years ago during evolution. It is the sole inhibitory receptor for IgG, and has long been associated with the regulation of humoral immunity and innate immune homeostasis. However, new and surprising functions of Fc?RIIB are emerging. In particular, Fc?RIIB has been shown to perform unexpected activatory roles in both immune-signaling and monoclonal antibody (mAb) immunotherapy. Furthermore, although ITIM signaling is an integral part of Fc?RIIB regulatory activity, it is now clear that inhibition/activation of immune responses can occur independently of the ITIM. In light of these new findings, we present an overview of the established and noncanonical functions of Fc?RIIB and discuss how this knowledge might be exploited therapeutically.

【 授权许可】

CC BY