Epigenetics of Tcell aging

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Jörg J. Goronzy¹  Bin Hu¹  Chulwoo Kim¹  Rohit R. Jadhav¹  Cornelia M. Weyand¹ 

[1] Division of Immunology and Rheumatology, Department of Medicine, Stanford University;Department of Medicine, Palo Alto Veterans Administration Healthcare System

关键词: chromatin accessibility;    DNA methylation;    histone modification;    immunosenescence;    T cell differentiation;    transcription factor;   

DOI  :  10.1002/JLB.1RI0418-160R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

T cells are a heterogeneous population of cells that differ in their differentiation stages. Functional states are reflected in the epigenome that confers stability in cellular identity and is therefore important for naïve as well as memory T cell function. In many cellular systems, changes in chromatin structure due to alterations in histone expression, histone modifications and DNA methylation are characteristic of the aging process and cause or at least contribute to cellular dysfunction in senescence. Here, we review the epigenetic changes in T cells that occur with age and discuss them in the context of canonical epigenetic marks in aging model systems as well as recent findings of chromatin accessibility changes in T cell differentiation. Remarkably, transcription factor networks driving T cell differentiation account for many of the age-associated modifications in chromatin structures suggesting that loss of quiescence and activation of differentiation pathways are major components of T cell aging.

【 授权许可】

CC BY