Eosinophil and airway nerve interactions in asthma

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Matthew G. Drake¹  Katherine M. Lebold¹  Quinn R. Roth-Carter¹  Alexandra B. Pincus¹  Emily D. Blum¹  Becky J. Proskocil¹  David B. Jacoby¹  Allison D. Fryer¹  Zhenying Nie¹ 

[1] Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University

关键词: asthma;    eosinophil;    major basic protein;    parasympathetic nerve;    sensory nerve;   

DOI  :  10.1002/JLB.3MR1117-426R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Airway eosinophils are increased in asthma and are especially abundant around airway nerves. Nerves control bronchoconstiction and in asthma, airway hyperreactivity (where airways contract excessively to inhaled stimuli) develops when eosinophils alter both parasympathetic and sensory nerve function. Eosinophils release major basic protein, which is an antagonist of inhibitory M2 muscarinic receptors on parasympathetic nerves. Loss of M2 receptor inhibition potentiates parasympathetic nerve-mediated bronchoconstriction. Eosinophils also increase sensory nerve responsiveness by lowering neurons’ activation threshold, stimulating nerve growth, and altering neuropeptide expression. Since sensory nerves activate parasympathetic nerves via a central neuronal reflex, eosinophils’ effects on both sensory and parasympathetic nerves potentiate bronchoconstriction. This review explores recent insights into mechanisms and effects of eosinophil and airway nerve interactions in asthma.

【 授权许可】

CC BY