CD71+ erythroid cells from neonates born to women with preterm labor regulate cytokine and cellular responses

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Derek Miller¹  Roberto Romero¹  Ronald Unkel¹  Yi Xu¹  Felipe Vadillo-Ortega¹  Sonia S. Hassan¹  Nardhy Gomez-Lopez¹ 

[1] Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development;Department of Obstetrics and Gynecology, Wayne State University School of Medicine;Department of Immunology, Wayne State University School of Medicine;Department of Obstetrics and Gynecology, University of Michigan;Department of Epidemiology and Biostatistics, Michigan State University;Center for Molecular Medicine and Genetics, Wayne State University;Branch at Instituto Nacional de Medicina Genomica;Department of Physiology, Wayne State University School of Medicine

关键词: cytokines;    human;    myeloid cells;    neonatal immunity;    parturition;    pregnancy;    premature;    regulatory T cells;    T cells;    umbilical cord blood;   

DOI  :  10.1002/JLB.5A0717-291RRR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Neonatal CD71+ erythroid cells are thought to have immunosuppressive functions. Recently, we demonstrated that CD71+ erythroid cells from neonates born to women who underwent spontaneous preterm labor (PTL) are reduced to levels similar to those of term neonates; yet, their functional properties are unknown. Herein, we investigated the functionality of CD71+erythroid cells from neonates born to women who underwent spontaneous preterm or term labor. CD71+ erythroid cells from neonates born to women who underwent PTL displayed a similar mRNA profile to that of those from term neonates. The direct contact between preterm or term neonatal CD71+ erythroid cells and maternal mononuclear immune cells, but not soluble products from these cells, induced the release of proinflammatory cytokines and a reduction in the release of TGF-?. Moreover, PTL-derived neonatal CD71+ erythroid cells (1) modestly altered CD8+ T cell activation; (2) inhibited conventional CD4+ and CD8+ T-cell expansion; (3) suppressed the expansion of CD8+ regulatory T cells; (4) regulated cytokine responses mounted by myeloid cells in the presence of a microbial product; and (5) indirectly modulated T-cell cytokine responses. In conclusion, neonatal CD71+ erythroid cells regulate neonatal T-cell and myeloid responses and their direct contact with maternal mononuclear cells induces a proinflammatory response. These findings provide insight into the biology of neonatal CD71+ erythroid cells during the physiologic and pathologic processes of labor.

【 授权许可】

CC BY