From top to bottom: midkine and pleiotrophin as emerging players in immune regulation

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

Brekken, Rolf A.¹  Dominguez, Adrian T. A.³ 

[1] and;and..Division of Surgical Oncology, Departments of Surgery and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA;Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA

关键词: hematopoiesis;    myeloid cells;    lymphoid cells;    cytokines;   

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Cytokines are pivotal in the generation and resolution of the inflammatory response. The midkine/pleiotrophin (MK/PTN) family of cytokines, composed of just two members, was discovered as heparin-binding neurite outgrowth-promoting factors. Since their discovery, expression of this cytokine family has been reported in a wide array of inflammatory diseases and cancer. In this minireview, we will discuss the emerging appreciation of the functions of the MK/PTN family in the immune system, which include promoting lymphocyte survival, sculpting myeloid cell phenotype, driving immune cell chemotaxis, and maintaining hematopoiesis.

【 授权许可】

CC BY