Looking back at multidrug resistance (MDR) research and ten mistakes to be avoided when writing about ABC transporters in MDR

FEBS Letters

article

Piet Borst¹ 

[1] Division of Cell Biology, The Netherlands Cancer Institute

关键词: ABC transporters;    cancer;    grant application;    knockout mice;    multidrug resistance;   

DOI  :  10.1002/1873-3468.13972

来源: John Wiley & Sons Ltd.

【 摘 要 】

This paper presents a personal, selective, and sometimes critical retrospective of the history of ABC transporters in multidrug resistance (MDR) of cancer cells, overrepresenting discoveries of some early pioneers, long forgotten, and highlights of research in Amsterdam, mainly focussing on discoveries made with disruptions of ABC genes in mice (KO mice) and on the role of ABC transporters in causing drug resistance in a mouse model of mammary cancer. The history is complemented by a list of erroneous concepts often found in papers and grant applications submitted anno 2020.

【 授权许可】

Unknown