Restriction point regulation at the crossroads between quiescence and cell proliferation

FEBS Letters

article

Betheney R. Pennycook¹  Alexis R. Barr¹ 

[1] Institute of Clinical Sciences, Faculty of Medicine, Imperial College London;MRC London Institute of Medical Sciences, Imperial College London

关键词: cell cycle;    cyclin;    cyclin-dependent kinase;    proliferation;    quiescence;    restriction point;    single-cell imaging;   

DOI  :  10.1002/1873-3468.13867

来源: John Wiley & Sons Ltd.

【 摘 要 】

The coordination of cell proliferation with reversible cell cycle exit into quiescence is crucial for the development of multicellular organisms and for tissue homeostasis in the adult. The decision between quiescence and proliferation occurs at the restriction point, which is widely thought to be located in the G1 phase of the cell cycle, when cells integrate accumulated extracellular and intracellular signals to drive this binary cellular decision. On the molecular level, decision-making is exerted through the activation of cyclin-dependent kinases (CDKs). CDKs phosphorylate the retinoblastoma (Rb) transcriptional repressor to regulate the expression of cell cycle genes. Recently, the classical view of restriction point regulation has been challenged. Here, we review the latest findings on the activation of CDKs, Rb phosphorylation and the nature and position of the restriction point within the cell cycle.

【 授权许可】

Unknown