Cell transformation by the adenovirus oncogenes E1 and E4

FEBS Letters

article

Wing Hang Ip¹  Thomas Dobner¹ 

[1] Heinrich Pette Institute, Leibniz Institute for Experimental Virology

关键词: CBP;    E1A;    E1B-55K;    E4;    human adenovirus;    oncogene;    p300;    p53;    pRb;    transformation;   

DOI  :  10.1002/1873-3468.13717

来源: John Wiley & Sons Ltd.

【 摘 要 】

Extensive studies on viral-mediated oncogenic transformation by human adenoviruses have revealed much of our current understanding on the molecular mechanisms that are involved in the process. To date, these studies have shown that cell transformation is a multistep process regulated by the cooperation of several adenoviral gene products encoded in the early regions 1 (E1) and 4 (E4). Early region 1A immortalizes primary rodent cells, whereas coexpression of early region protein 1B induces full manifestation of the transformed phenotype. Beside E1 proteins, also some E4 proteins have partial transforming activities through regulating many cellular pathways. Here, we summarize recent data of how adenoviral oncoproteins may contribute to viral transformation and discuss the challenge of pinpointing the underlying mechanisms.

【 授权许可】

Unknown