Adenovirus 2 E1B‐55K protein relieves p53‐mediated transcriptional repression of the survivin and MAP4 promoters

FEBS Letters

Punga, Tanel¹  Akusjärvi, Göran¹ 

[1] Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, 751 23 Uppsala, Sweden

关键词: Adenovirus;    E1B-55K;    Survivin;    Sin3A;   

DOI  :  10.1016/S0014-5793(03)00927-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It is well established that adenovirus E1B-55K protein functions as an inhibitor of the tumor suppressor protein p53 by binding and inactivating p53 as a transcriptional activator protein. Here we show that the adenovirus 2 E1B-55K protein also blocks p53 as a transcriptional repressor protein of the survivin and the MAP4 promoters. The repression is dependent on the ability of E1B-55K to bind to p53 and is enhanced by coexpression of the adenovirus E4orf6 protein. Overexpression of the transcriptional corepressor protein Sin3A partially relieves the inhibitory effect of E1B-55K, suggesting that E1B-55K blocks p53 functions by interfering with the Sin3 complex.

【 授权许可】

Unknown