FEBS Letters | |
Adenovirus 2 E1B‐55K protein relieves p53‐mediated transcriptional repression of the survivin and MAP4 promoters | |
Punga, Tanel1  Akusjärvi, Göran1  | |
[1] Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, 751 23 Uppsala, Sweden | |
关键词: Adenovirus; E1B-55K; Survivin; Sin3A; | |
DOI : 10.1016/S0014-5793(03)00927-X | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
It is well established that adenovirus E1B-55K protein functions as an inhibitor of the tumor suppressor protein p53 by binding and inactivating p53 as a transcriptional activator protein. Here we show that the adenovirus 2 E1B-55K protein also blocks p53 as a transcriptional repressor protein of the survivin and the MAP4 promoters. The repression is dependent on the ability of E1B-55K to bind to p53 and is enhanced by coexpression of the adenovirus E4orf6 protein. Overexpression of the transcriptional corepressor protein Sin3A partially relieves the inhibitory effect of E1B-55K, suggesting that E1B-55K blocks p53 functions by interfering with the Sin3 complex.
【 授权许可】
Unknown
【 预 览 】
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RO201912020313381ZK.pdf | 206KB | download |