Molecular evidence for the evolution of the eukaryotic mitochondrial arginyl-tRNA synthetase from the prokaryotic suborder Cystobacterineae

FEBS Letters

article

Gabor L. Igloi¹ 

[1] Institute of Biology, University of Freiburg

关键词: bacterial endosymbiont;    eukaryotic arginyl-tRNA synthetase;    mitochondrial gene;    molecular evolution;    multiple sequence alignment;    sequence conservation;   

DOI  :  10.1002/1873-3468.13665

来源: John Wiley & Sons Ltd.

【 摘 要 】

The evolutionary origin of the family of eukaryotic aminoacyl-tRNA synthetases that are essential to all living organisms is a matter of debate. In order to shed molecular light on the ancient source of arginyl-tRNA synthetase, a total of 1347 eukaryotic arginyl-tRNA synthetase sequences were mined from databases and analyzed. Their multiple sequence alignment reveals a signature sequence that is characteristic of the nuclear-encoded enzyme, which is imported into mitochondria. Using this molecular beacon, the origins of this gene can be traced to modern prokaryotes. In this way, a previous phylogenetic analysis linking Myxococcus to the emergence of the eukaryotic mitochondrial arginyl-tRNA synthetase is supported by the unique existence of the molecular signature within the suborder Cystobacterineae that includes Myxococcus.

【 授权许可】

Unknown