Mitotic cyclin Clb4 is required for the intracellular adaptation to glucose starvation in Saccharomycescerevisiae

FEBS Letters

article

Midori Umekawa¹  Daiki Shiraishi²  Marin Fuwa²  Kazuna Sawaguchi²  Yosuke Mashima³  Takane Katayama³  Shuichi Karita¹ 

[1] Graduate School of Bioresources, Mie University;Faculty of Bioresources, Mie University;Graduate School of Biostudies, Kyoto University

关键词: autophagy;    glucose starvation;    nutrient response;   

DOI  :  10.1002/1873-3468.13722

来源: John Wiley & Sons Ltd.

【 摘 要 】

Cellular homeostasis in response to glucose availability is maintained through the tight coordination of various physiological processes, including cell proliferation, transcription, and metabolism. In this study, we use the budding yeast Saccharomyces cerevisiae to identify proteins implicated in carbon source-dependent modulation of physiological processes. We find that the mitotic cyclin Clb4 is required for optimal regulation of glucose-starvation-responsive pathways through the target of rapamycin complex 1. Cells lacking Clb4 are characterized by dysregulation of autophagy and impaired modulation of cell size. Notably, cell viability after prolonged glucose starvation is severely reduced by disruption of Clb4. We conclude that Clb4, in addition to its function in the cell cycle, plays a role in the intracellular adaptation to glucose starvation.

【 授权许可】

Unknown