Streptococcus pyogenes upregulates arginine catabolism to exert its pathogenesis on the skin surface

Cell Reports

Tomoko Sumitomo¹  Masaya Yamaguchi²  Masanobu Hiraoka³  Raymond H. Zurich⁴  Satoshi Uchiyama⁵  Hiroshi Kawasaki⁶  Daisuke Okuzaki⁷  Masanobu Nakata⁸  Tomoki Hanada⁸  Daisuke Motooka⁸  Yujiro Hirose⁸  Alison Coady⁸  Masayuki Amagai⁹  Victor Nizet⁹  Shigetada Kawabata⁹  Yasushi Mori^1,10 

[1] Corresponding author;Department of Pediatrics, University of California at San Diego School of Medicine, La Jolla, CA 92093, USA;Immunology Data Integration Unit, RIKEN Medical Sciences Innovation Hub Program, Yokohama 230-0045, Japan;Laboratory for Skin Homeostasis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan;Department of Dermatology, Keio University School of Medicine, Tokyo 160-8582, Japan;Department of Infection Metagenomics, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan;Department of Oral Microbiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan;Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565-0871, Japan;Department of Pediatrics, University of California at San Diego School of Medicine, La Jolla, CA 92093, USA;Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan;

关键词: Streptococcus pyogenes;    arginine;    arginine deiminase pathway;    bacterial viability;    bacterial pathogenesis;    glucose starvation;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: The arginine deiminase (ADI) pathway has been found in many kinds of bacteria and functions to supplement energy production and provide protection against acid stress. The Streptococcus pyogenes ADI pathway is upregulated upon exposure to various environmental stresses, including glucose starvation. However, there are several unclear points about the advantages to the organism for upregulating arginine catabolism. We show that the ADI pathway contributes to bacterial viability and pathogenesis under low-glucose conditions. S. pyogenes changes global gene expression, including upregulation of virulence genes, by catabolizing arginine. In a murine model of epicutaneous infection, S. pyogenes uses the ADI pathway to augment its pathogenicity by increasing the expression of virulence genes, including those encoding the exotoxins. We also find that arginine from stratum-corneum-derived filaggrin is a key substrate for the ADI pathway. In summary, arginine is a nutrient source that promotes the pathogenicity of S. pyogenes on the skin.

【 授权许可】

Unknown