Protein-facilitated transport of hydrophobic molecules across the yeast plasma membrane

FEBS Letters

article

Silke Claus¹  Sylwia Jezierska¹  Inge N. A. Van Bogaert² 

[1] Universiteit Gent;Lab. of Industrial Microbiology and Biocatalysis, Faculty of Bioscience Engineering, Ghent University

关键词: alkane;    drug;    fatty acid;    hydrophobic compound;    mating factor;    plasma membrane;    sterol;    transport;    xenobiotic;    yeast;   

DOI  :  10.1002/1873-3468.13469

来源: John Wiley & Sons Ltd.

【 摘 要 】

In yeasts, the plasma membrane forms the barrier that protects the cell from the outside world, but also gathers and keeps valuable compounds inside. Although it is often suggested that hydrophobic molecules surpass this checkpoint by simple diffusion, it now becomes evident that protein-facilitated transport mechanisms allow for selective import and export of triglycerides, fatty acids, alkanes, and sterols in yeasts. During biomass production, hydrophobic carbon sources enter and exit the cell efficiently in a strictly regulated manner that helps avoid toxicity. Furthermore, various molecules, such as yeast pheromones, secondary metabolites and xenobiotics, are exported to ensure cell–cell communication, or increase chances of survival. This review summarizes the current knowledge on how hydrophobic compounds interact with protein-facilitated transport systems on the plasma membrane and how selective import and export across the yeast plasma membrane is achieved. Both the model organism Saccharomyces cerevisiae, as well as unconventional yeasts are discussed.

【 授权许可】

Unknown