Overexpression of the dopamine receptor-interacting protein Alix/AIP1 modulates NMDA receptor-triggered cell death

FEBS Letters

article

Sharifah Salim¹  Jamal Nasir²  Philip E. Chen¹ 

[1] Centres for Biomedical Sciences and Gene & Cell Therapy, School of Biological Sciences, Royal Holloway, University of London;Molecular Biosciences Research Group, Faculty of Health & Society, University of Northampton, Waterside Campus

关键词: ALG-2;    calcium;    dopamine receptor interacting protein;    glutamate receptor;    neurodegeneration;    PDCD6IP;   

DOI  :  10.1002/1873-3468.13434

来源: John Wiley & Sons Ltd.

【 摘 要 】

Alix/AIP1 is an adaptor protein involved in apoptosis, endocytic membrane trafficking and brain development. Alix has been found within the human postsynaptic density (PSD) and, since NMDA receptors (NMDARs) are central components of the PSD, we hypothesized that the close proximity of both proteins may allow Alix to influence the downstream pathways following NMDAR activation. NMDARs play important roles in excitotoxicity and we evaluated the effects of recombinant Alix in an NMDAR cell death assay. Overexpression of Alix with NMDARs increases the potency of NMDARinduced cell death compared to cells expressing only NMDARs, and this requires expression of the Alix C-terminal region. Therefore, we demonstrate a previously unreported role for Alix as a potential modulator of NMDAR function.

【 授权许可】

Unknown