Nudt8 is a novel CoA diphosphohydrolase that resides in the mitochondria

FEBS Letters

article

Evan W. Kerr¹  Stephanie A. Shumar¹  Roberta Leonardi¹ 

[1] Department of Biochemistry, West Virginia University

关键词: cell compartmentalization;    Coenzyme A;    metabolic regulation;    mitochondria;    Nudix hydrolase;   

DOI  :  10.1002/1873-3468.13392

来源: John Wiley & Sons Ltd.

【 摘 要 】

CoA regulates energy metabolism and exists in separate pools in the cytosol, peroxisomes, and mitochondria. At the whole tissue level, the concentration of CoA changes with the nutritional state by balancing synthesis and degradation; however, it is currently unclear how individual subcellular CoA pools are regulated. Liver and kidney peroxisomes contain Nudt7 and Nudt19, respectively, enzymes that catalyze CoA degradation. We report that Nudt8 is a novel CoA-degrading enzyme that resides in the mitochondria. Nudt8 has a distinctive preference for manganese ions and exhibits a broader tissue distribution than Nudt7 and Nudt19. The existence of CoA-degrading enzymes in both peroxisomes and mitochondria suggests that degradation may be a key regulatory mechanism for modulating the intracellular CoA pools.

【 授权许可】

Unknown