Regulatory T cells sense effector T-cell activation through synchronized JunB expression

FEBS Letters

article

Jingxia Wu¹  Sicong Ma¹  Agnes Hotz-Wagenblatt³  Peter Angel⁴  Kerstin Mohr¹  Tilo Schlimbach¹  Michael Schmitt²  Guoliang Cui¹ 

[1] T Cell Metabolism Group (D140), German Cancer Research Center (DKFZ);Medical Faculty Heidelberg, Heidelberg University;Core Facility Omics IT and Data Management, German Cancer Research Center (DKFZ);Division Signal Transduction and Growth Control (A100), German Cancer Research Center (DKFZ);University Heidelberg Hospital;Faculty of Biosciences, Heidelberg University

关键词: antitumor T cells;    autoimmunity;    effector T cells;    JunB;    Tregs;   

DOI  :  10.1002/1873-3468.13393

来源: John Wiley & Sons Ltd.

【 摘 要 】

To maintain immune tolerance, effector T-cell (Teff) responses must be checked by the regulatory T cells (Tregs) in time. It remains incompletely understood how Tregs sense real-time Teff activation. Here, we report that the AP-1 transcription factor JunB, which is induced in Teffs upon T-cell receptor (TCR) activation, is also increased in Tregs by TCR stimuli. Tregspecific deletion of Junb impairs Treg identity, causes uncontrolled inflammatory cytokine production by Teffs and leads to the T-box transcription factor T-bet-dependent spontaneous inflammation. Furthermore, JunB deficiency in Tregs unleashes antitumor Teff responses in a mouse model of melanoma. We conclude that JunB alarms Tregs of the emerging Teff activation and synchronizes immune regulation with the immune reaction in autoimmunity and cancer.

【 授权许可】

Unknown