Spatial organization of the transcriptional regulatory network of Saccharomycescerevisiae

FEBS Letters

article

Dong-Qing Sun¹  Liu Tian¹  Bin-Guang Ma¹ 

[1] Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University

关键词: 3D genome;    chromatin interaction;    network hierarchy;    network motif;    Saccharomyces cerevisiae;    transcriptional regulatory network;   

DOI  :  10.1002/1873-3468.13371

来源: John Wiley & Sons Ltd.

【 摘 要 】

A transcriptional regulatory network (TRN) is a complex network composed of all of the regulatory interactions between transcription factors and the corresponding target genes. Recently, three-dimensional (3D) genomic studies have shown that the 3D structure of the genome may influence the regulation of gene transcription, which provides us with a novel perspective. In the present study, we constructed the TRN of the budding yeast Saccharomyces cerevisiae and placed it in the context of a 3D genome model. We analyzed the spatial organization of the yeast TRN on four levels: global features, central nodes, hierarchical structure and network motifs. The results obtained suggest that the TRN of S. cerevisiae presents an optimized structure in space to adapt to functional requirements.

【 授权许可】

Unknown