Prevalence and Risk Factors for Positive Surgical Margin after Loop Electrosurgical Excision Procedure (LEEP) in Patients with High Grade Squamous Intraepithelial Lesion

Thai Journal of Obstetrics and Gynaecology

article

Palaporn Kanjanasirirut¹  Kamol Pataradool¹  Sumonmal Manusirivithaya¹  Chadakarn Phaloprakarn¹  Chutima Chavanisakun² 

[1] Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University;Department of Pathology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University

关键词: HSIL;    positive margin;    LEEP;   

DOI  :  10.14456/tjog.2015.23

学科分类：社会科学、人文和艺术（综合）

来源: The Royal Thai College of Obstetricians and Gynaecologists

【 摘 要 】

Objective: To determine the prevalence and risk factors for positive surgical margin after LEEP in patients with high grade squamous intraepithelial lesion (HSIL). Material and Methods: Medical records of all women (n = 575) who underwent LEEP and histopathological diagnosed HSIL between January 2008 and December 2012 in our institution were reviewed. The margins of surgical specimens were re-evaluated by a pathologist. Clinical data and status of surgical margin were recorded. The prevalence and risk factors for positive surgical margin were analyzed.    Results: Complete data of 547 women with HSIL who underwent LEEP were obtained. Mean age of the women was 41.8 ± 12.5 years (ranging from 17 to 75 years). The majority of them were multiparous (n = 405 or 74.1%) and premenopause (n=464 or 84.8%). Positive LEEP surgical margin was found in 167 cases (30.5 %). In multivariable analysis, multiparity and glandular involvement were two independent risk factors for positive LEEP surgical margin; adjusted relative risk of 8.10 (95% confidence interval, 3.82-17.20) and 14.10 (95% confidence interval, 8.34-23.83), respectively. Conclusion: The prevalence of positive margin in women with HSIL who underwent LEEP was 30.5 %. Multiparity and glandular involvements were significant factors associated with the margin involvement.

【 授权许可】

CC BY-NC-ND