PrevalenceandRiskFactorsforPositiveSurgicalMarginafterLoopElectrosurgicalExcisionProcedure(LEEP)inPatients with High Grade Squamous Intraepithelial Lesion

Thai Journal of Obstetrics and Gynaecology

Sumonmal Manusirivithaya¹  Palaporn Kanjanasirirut¹  Chadakarn Phaloprakarn¹  Kamol Pataradool¹  Chutima Chavanisakun² 

[1] DepartmentofObstetricsandGynecology,FacultyofMedicineVajiraHospital,NavamindradhirajUniversity,Bangkok,Thailand;Department of Pathology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand;

关键词: HSIL;    positive margin;    LEEP;   

DOI  :  https://doi.org/10.14456/tjog.2015.23

来源: DOAJ

【 摘 要 】

Objective: To determine the prevalence and risk factors for positive surgical margin after LEEP in patients with high grade squamous intraepithelial lesion (HSIL). Material and Methods:Medicalrecordsofallwomen(n=575)whounderwentLEEPandhistopathological diagnosed HSIL between January 2008 and December 2012 in our institution were reviewed. The margins of surgical specimens were re-evaluated by a pathologist. Clinical data and status of surgical margin were recorded. The prevalence and risk factors for positive surgical margin were analyzed.Results:Complete data of 547 women with HSIL who underwent LEEP were obtained. Mean age of the women was 41.8 ± 12.5 years (ranging from 17 to 75 years). The majority of them were multiparous (n = 405 or 74.1%) and premenopause (n = 464 or 84.8%).Positive LEEP surgicalmarginwasfoundin167cases(30.5%).Inmultivariableanalysis,multiparityandglandularinvolvementweretwoindependentriskfactorsforpositiveLEEPsurgicalmargin;adjusted relative risk of 8.10 (95% confidence interval, 3.82-17.20) and 14.10 (95% confidence interval, 8.34-23.83), respectively.Conclusions:The prevalence of positive margin in women with HSIL who underwent LEEP was 30.5%.Multiparityandglandularinvolvementsweresignificantfactorsassociatedwiththemargin involvement.

【 授权许可】

Unknown