Lungs of COVID-19 affected patients: an autoptic morphological profile

Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche

article

Giovanni Tuccari¹  Gaetano Caramori²  Vittorio Cavallari¹  Guido Fadda¹  Antonio Ieni¹ 

[1] Department of Human Pathology of Adult and Developmental Age “Gaetano Barresi” – Section of Pathology, Azienda OspedalieraUniversitaria "Policlinico G. Martino" Messina;Department of Biomedical Sciences, Odontoiatrics, Morphologic and Functional Images - Section of Pulmonology, University of Messina, Azienda OspedalieraUniversitaria "Policlinico G. Martino" Messina

关键词: Coronavirus;    autopsy;    lung tissue;    alveoli;    endothelial cells;    viral-like particles;   

DOI  :  10.6092/1828-6550/APMB.108.2.2020.SD5

学科分类：农业科学（综合）

来源: Accademia Peloritana dei Pericolanti

【 摘 要 】

Current knowledge concerning the recently occurred Coronavirus disease 2019 (COVID-19) is largely based on human and laboratory reports, even if pathogenic mechanisms have been greatly elucidated by autoptic procedures. Consequently, the aim of this study is to describe macroscopic changes and histopathological findings documented in lung tissue of these patients. Moreover, the need of an optimised autopsy protocol and the application of ancillary techniques, such as immunohistochemistry (IlHC), in situ hybridization (ISH), PCR-based assay and electron microscopy, have to be recorded in order to assess the presence of COVID-19 virus-like particles in lung tissue, although the risk of autolytic changes as well the incorrect interpretation of artefacts should be cautiously considered.

【 授权许可】

CC BY