Irreversible acute kidney injury following efavirenz/tenofovir disoproxil fumarate/emtricitabine overdose

African Journal of Nephrology

article

Jason Ensor¹  Shumani Malaka  Benita Barton²  John Black¹  Robert Freercks¹ 

[1] University of Cape Town;Nelson Mandela University

关键词: Africa;    AKI;    tenofovir overdose;    HIV;    dialysis;   

DOI  :  10.21804/21-1-2748

学科分类：数学（综合）

来源: African Association of Nephrology

【 摘 要 】

Nephrotoxicity due to chronic use of tenofovir disoproxil fumarate (TDF) is well described, but very little is known or published about the effects of acute toxicity or the clinical management of this condition. We present here a case of acute and irreversible renal failure that followed an intentional overdose of fixed dose combination antiretroviral therapy containing efavirenz, TDF and emtricitabine. The renal histology findings are discussed and a rationale for the use of emergency haemodialysis in the management of TDF overdose is presented.

【 授权许可】

CC BY