期刊论文详细信息
Journal of Insulin Resistance | |
The fructose–copper connection: Added sugars induce fatty liver and insulin resistance via copper deficiency | |
article | |
James J. DiNicolantonio1  Dennis Mangan2  James H. O',Keefe1  | |
[1]Department of Preventive Cardiology, Saint Luke’s Mid America Heart Institute | |
[2]Independent Researcher | |
关键词: copper; fructose; sucrose; sugar; fatty liver; | |
DOI : 10.4102/jir.v3i1.43 | |
来源: AOSIS | |
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【 摘 要 】
Background: Evidence suggests that the overconsumption of added sugars can induce fatty liver disease and insulin resistance. Aim: To propose a hypothesis that added sugars induce copper deficiency which can lead to hepatic iron overload, fatty liver disease, insulin resistance and eventually non-alcoholic steatohepatitis. Setting: On average, the intake of added sugars in humans is higher than levels that have been found to impair copper status in animals. Methods: Narrative review. Results: Fructose-induced copper deficiency may be a leading cause of fatty liver disease and insulin resistance. Conclusion: The reduction in the intake of added sugars may improve copper status and reduce the risk of fatty liver disease and insulin resistance.【 授权许可】
CC BY
【 预 览 】
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