The fructose–copper connection: Added sugars induce fatty liver and insulin resistance via copper deficiency

Journal of Insulin Resistance

article

James J. DiNicolantonio¹  Dennis Mangan²  James H. O',Keefe¹ 

[1] Department of Preventive Cardiology, Saint Luke’s Mid America Heart Institute;Independent Researcher

关键词: copper;    fructose;    sucrose;    sugar;    fatty liver;   

DOI  :  10.4102/jir.v3i1.43

来源: AOSIS

【 摘 要 】

Background:  Evidence suggests that the overconsumption of added sugars can induce fatty liver disease and insulin resistance. Aim:  To propose a hypothesis that added sugars induce copper deficiency which can lead to hepatic iron overload, fatty liver disease, insulin resistance and eventually non-alcoholic steatohepatitis. Setting:  On average, the intake of added sugars in humans is higher than levels that have been found to impair copper status in animals. Methods:  Narrative review. Results:  Fructose-induced copper deficiency may be a leading cause of fatty liver disease and insulin resistance. Conclusion:  The reduction in the intake of added sugars may improve copper status and reduce the risk of fatty liver disease and insulin resistance.

【 授权许可】

CC BY