Type 2 diabetes mellitus, physical activity, yoga and telomere length: A literature review

Journal of Insulin Resistance

article

Reepa A. Ughreja¹  Reena A. Ughreja² 

[1]Department of Physiotherapy, Manipal College of Health Professions

[2]Department of Pharmaceutical Sciences, Saurashtra University

关键词: Type 2 Diabetes Mellitus;    Yoga;    Physical Activity;    Telomere Length;    Quality of Life;   

DOI  :  10.4102/jir.v4i1.52

来源: AOSIS

【 摘 要 】

Background: Type 2 diabetes mellitus (DM), a chronic metabolic disease prevalent in adults, is also prevalent amongst children, adolescents and young adults. On understanding the molecular basis of diabetes, a significant association is found between telomere length (TL) and type 2 DM. Aim: The aim of the study was to review the available evidence on effect of physical activity and yoga on DM including their effect on TL. Setting: The study was conducted in Bangalore. Method: A number of databases such as Google Scholar, PubMed and Cochrane Review were searched for relevant articles using keywords such as ’diabetes’, ‘type 2 DM’, ‘physical activity’, ‘yoga’, ‘TL’ and ‘telomerase activity’. All types of articles were included for the study, such as randomised controlled trial, systematic reviews, literature review and pilot study. Non-English articles were excluded from the study. Results: Studies have demonstrated the effectiveness of yoga and physical exercise in type 2 DM in various ways, such as reducing fasting blood glucose and glycosylated haemoglobin; improving lipid profile, blood pressure and waist-to-hip ratio; reducing inflammatory, oxidative and psychological stress markers; and improving the quality of life of patients. However, limited information is available on the effect of these interventions on TL in type 2 DM and mechanisms involved. Conclusion: Recent studies have shown positive effects of yoga and physical activity on TL. However, there is a dearth of good-quality studies evaluating the effects of yoga on TL in type 2 DM. Future studies need to be conducted with standard treatment protocols, long-term follow-up, appropriate control groups and large sample size.

【 授权许可】

CC BY