Prognostic relevance of ALT-associated markers in liposarcoma: a comparative analysis

BMC Cancer

Research Article

MariaGrazia Daidone¹  Lorenza Venturini¹  Nadia Zaffaroni¹  Rosita Motta¹  Alessandro Gronchi² 

[1] Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy;

关键词: Telomere Length;    Liposarcoma;    Telomeric Repeat Amplification Protocol;    Telomeric Repeat Amplification Protocol;    Telomere Maintenance Mechanism;   

DOI  :  10.1186/1471-2407-10-254

 received in 2010-02-02, accepted in 2010-06-03,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundMost cancers maintain telomeres by activating telomerase but a significant minority, mainly of mesenchymal origin, utilize an alternative lengthening of telomeres (ALT) mechanism.MethodsIn this study we comparatively analyzed the prognostic relevance of ALT in a monoinstitutional series of 85 liposarcoma patients as a function of the marker (ALT-associated promyelocytic leukemia bodies (APB) versus heterogeneous telomeres) used to classify the tumor.ResultsIndependently of the detection approach, ALT proved to be a prognostic discriminant of increased mortality, although the prognostic relevance of the two markers appeared at different follow-up intervals (at 10 years for APB and 15 years for telomeres).ConclusionsOverall, we confirmed ALT as an indicator of poor clinical outcome in this disease and provide the first evidence that the sensitivity of the ALT predictive power depends, at least in part, on the method used.

【 授权许可】

Unknown   
© Venturini et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.