The molecular pathology of thyroid neoplasms

Journal of Pathology of Nepal

article

JB Thapa¹ 

[1] Department of Pathology, Himal Hospital Pvt. Ltd.

关键词: Thyroid;    Tumours;    Bethesda System;    RAS;    BRAF;    p53;    B Catenin;    PAX8/PPAR?;    Biological behavior;    Gene therapy;   

DOI  :  10.3126/jpn.v4i7.10317

来源: Alma Ata University Press

【 摘 要 】

The Bethesda system of reporting thyroid cytology is being currently adopted worldwide. Rapid advances have been made in the understanding of the genetics of thyroid cancers. Common genetic mutations include RAS, BRAF, p53, B Catenin, and PAX8/PPARγ, genes. BRAF mutations tumours are often aggressive. BRAF mutations commonly affect papillary carcinomas in the BRAF MEK ERF intracellular pathway, whereas RAS mutations commonly affect follicular carcinoma in the PL3 kinase pathway. TK inhibitors, RAS, RET, non RET, PL3, HDAC, DNMT etc. inhibitors are also being considered for therapy against these tumours.

【 授权许可】

CC BY