Gridlock from diagnosis to treatment of multidrug resistant tuberculosis (MDR-TB) in Tanzania: patients’ perspectives from a focus group discussion

BMC Public Health

Scott K. Heysell¹  Kristen Petros de Guex¹  Gibson S. Kibiki²  Stellah G. Mpagama³  Peter M. Mbelele³  Anna M. Chongolo³  Mangi J. Ezekiel⁴ 

[1] Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA;East African Health Research Commission, Bujumbura, Burundi;Kibong’oto Infectious Diseases Hospital –Sanya Juu Siha/Kilimanjaro Clinical Research Institute Kilimanjaro Tanzania, Mae Street, Lomakaa road, Siha Kilimanjaro, Tanzania;Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania;

关键词: Multidrug resistant tuberculosis (MDR-TB);    Focus group discussion;    Qualitative research;    Molecular diagnostics;    Health systems;    Health care workers;    Implementation;   

DOI  :  10.1186/s12889-020-09774-3

来源: Springer

【 摘 要 】

BackgroundMolecular diagnostics have revolutionized the diagnosis of multidrug resistant tuberculosis (MDR-TB). Yet in Tanzania we found delay in diagnosis with more than 70% of MDR-TB patients having a history of several previous treatment courses for TB signaling prior opportunities for diagnosis. We aimed to explore patients’ viewpoints and experiences with personal and socio-behavioral obstacles from MDR-TB diagnosis to treatment in an attempt to understand these prior findings.MethodsThe study was conducted in December 2016 with MDR-TB patients admitted at Kibong’oto Infectious Diseases Hospital. A qualitative approach deploying focus group discussions (FGDs) was used to gather information. Groups were sex aggregated to allow free interaction and to gauge gender specific issues in the social and behavioral contexts. The FGDs explored pathways and factors in the service delivery that may have contributed in the delay in accessing MDR-TB diagnostics and/or treatment. Collected data were coded, categorized and thematically interpreted.ResultsForty MDR-TB patients participated in six FGDs. Challenges and barriers contributing to the delay in accessing MDR-TB diagnosis to treatment were as follows: 1) Participants had a different understanding of MDR-TB that led to seeking services outside the conventional health system; 2) Socio-economic adversity made health-seeking behavior difficult and often unproductive; 3) In the health system, challenges included inadequacy of MDR-TB diagnostic centers, lack of knowledge on behalf of health care providers to consider MDR-TB and order appropriate diagnostics; 4) The specimen referral system for early diagnosis of MDR-TB was inefficient. Non-adherence of TB patients to first-line anti-TB drugs prior to MDR-TB diagnosis, given the multitude of barriers discussed, was coupled with both intentional and unintentional non-adherence of health care providers to international standards of TB care.ConclusionPatient-centered strategies bridging communities and the health system are urgently required for optimum MDR-TB control in Tanzania.

【 授权许可】

CC BY