Longitudinal change in arterial stiffness after delivery in women with preeclampsia and normotension: a prospective cohort study

BMC Pregnancy and Childbirth

Hyun Ja LIM¹  Jeung-Ran KIM²  Jung-Won SUH²  Sehun KIM³  Joon-Seok HONG⁴  Kyung Joon OH⁴ 

[1] Department of Community Health & Epidemiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada;Department of Internal Medicine, Cardiovascular Center, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82 Gumi-ro, 173 Beon-gil, Bundang-gu, 13620, Seongnam, Republic of Korea;Department of Internal Medicine, Seongnam Citizens Hospital, Seongnam, Republic of Korea;Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82 Gumi-ro, 173 Beon-gil, Bundang-gu, 13620, Seongnam, Republic of Korea;

关键词: Blood pressure;    Cardiovascular diseases;    Cardio-ankle vascular index;    Longitudinal change;    Preeclampsia;    Pregnancy;    Vascular stiffness;   

DOI  :  10.1186/s12884-020-03374-0

来源: Springer

【 摘 要 】

BackgroundPreeclampsia is associated with increased arterial stiffness during pregnancy. However, data on the longitudinal change in arterial stiffness after delivery in women with preeclampsia are lacking. In this pilot study, we aimed to examine the longitudinal change in arterial stiffness using the cardio-ankle vascular index after delivery in women with preeclamptic and normotensive pregnancies.MethodsWe enrolled pregnant women with preeclampsia (n = 37) and normotension (n = 36) who gave birth at Seoul National University Bundang Hospital between March 2013 and May 2016, and followed-up at day 1, 6 months, and 12 months after delivery. The longitudinal change in the cardio-ankle vascular index and other variables (blood pressure, lipid profiles, serum creatinine, and liver enzymes) were compared between the two groups using the mixed-effects model, and interactions among the main predictors were examined.ResultsThe longitudinal change in the cardio-ankle vascular index did not significantly differ between the two groups (β = 0.11, 95% CI: − 0.31–0.54, p = 0.60). Predictors of the longitudinal change in the cardio-ankle vascular index included age, time since delivery, body mass index, and diabetes mellitus. Women with preeclampsia showed significantly elevated blood pressure, lipid profiles, serum creatinine, and liver enzymes compared to women with normotension over the course of 1 year of follow-up.ConclusionsPreeclampsia is associated with unfavorable blood pressure and metabolic indices after delivery. However, we found no difference in the longitudinal change in arterial stiffness between women with preeclampsia and normotension over the course of 1 year after delivery.Trial registrationRetrospectively registered at ClinicalTrials.gov on October 29, 2019 (NCT04142268).

【 授权许可】

CC BY