Effects of AMPD1 gene C34T polymorphism on cardiac index, blood pressure and prognosis in patients with cardiovascular diseases: a meta-analysis

BMC Cardiovascular Disorders

Research Article

Shu-Long Zhou¹  Shi-Yuan Zhao¹  Ai-Fang Feng¹  Huai-Xin Wang¹  Zhong-Hui Liu¹  Yan-Xin Zhu¹ 

[1] Department of Emergency, Weifang Yidu Central Hospital, No. 4138, Linglongshan Southern Road, 262500, Weifang, People’s Republic of China;

关键词: AMPD1;    Cardiovascular diseases;    C34T;    Polymorphism;    Cardiac indexes;    Blood pressure;    Prognosis;   

DOI  :  10.1186/s12872-017-0608-0

 received in 2017-03-16, accepted in 2017-06-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe meta-analysis was aimed to evaluate the effects of AMPD1 gene C34T polymorphism on cardiac function indexes, blood pressure and prognosis in patients with cardiovascular diseases (CVD).MethodsEligible studies were retrieved through a comprehensive search of electronic databases and manual search. Then the high-quality studies met the rigorous inclusion and exclusion criteria, as well as related to the subject was selected for the study. Comprehensive data analyses were conducted using STATA software 12.0.ResultsThe study results revealed that CVD patients with CT + TT genotype of AMPD1 C34T polymorphism presented elevated left ventricular ejection fraction (LVEF) (%) and reduced left ventricular end diastolic dimension (LVEDD) (mm) as compared with CC genotype, moreover, the subgroup analysis found that the LVEF (%) was markedly higher in heart failure (HF) patients carrying CT + TT genotype than CC genotype. Besides, the systolic blood pressure (SBP) (mmHg) in CVD patients with CT + TT genotype was obviously decreased in contrast with the CC genotype. Patients suffered from HF with different genotypes (CT + TT and CC) of AMPD1 C34T polymorphism exhibited no significant differences in total survival rate and cardiac survival rate.ConclusionsOur current meta-analysis indicated that the T allele of AMPD1 gene C34T polymorphism may be correlated with LVEF, LVEDD and SBP, which plays a protective role in the cardiac functions and blood pressure in CVD patients, but had no effects on total survival rate and cardiac survival rate for HF.

【 授权许可】

CC BY   
© The Author(s). 2017