MOFs-Based Nitric Oxide Therapy for Tendon Regeneration

Nano-Micro Letters

Ting Ying¹  He Xu¹  Yunxia Li²  Shiyi Chen²  Dandan Sheng²  Jun Chen²  Jian Zhang²  Haojun Zhao³ 

[1] College of Chemistry and Materials Science, Shanghai Normal University, 200234, Shanghai, People’s Republic of China;Department of Sports Medicine, Huashan Hospital, Fudan University, 200040, Shanghai, People’s Republic of China;Department of Ultrasound, Jing’an District Center Hospital, Fudan University, 200040, Shanghai, People’s Republic of China;

关键词: Nitric oxide;    Metal–organic frameworks;    Tendon;    Tissue regeneration;    Angiogenesis;   

DOI  :  10.1007/s40820-020-00542-x

来源: Springer

【 摘 要 】

tsA system that NO-loaded metal–organic frameworks encapsulated in PCL/Gel aligned coaxial scaffold is successfully constructed.The system enables to release NO slowly (1.67 nM h−1) and stably in a long period (15 d) without a burst release in the initial 48 h.The scaffold can promote the regeneration of the injured tendon with maturer collagen fibers and better mechanical properties by angiogenesis.

【 授权许可】

CC BY