pH-responsive and hyaluronic acid-functionalized metal–organic frameworks for therapy of osteoarthritis

Journal of Nanobiotechnology

Zetao Wang¹  Qiumei Lan²  Li Zheng³  Jinmin Zhao⁴  Feng Xiong⁵  Zainen Qin⁶  Haimin Chen⁶  Nihan Lan⁶  Yuan Yang⁷  Dan Kai⁸ 

[1] Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Life Sciences Institute, Guangxi Medical University, 530021, Nanning, China;Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Guangxi Collaborative Innovation Center for Biomedicine, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Guangxi Collaborative Innovation Center for Biomedicine, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Guangxi Key Laboratory of Regenerative Medicine, Life Sciences Institute, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Guangxi Collaborative Innovation Center for Biomedicine, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Orthopaedics, Langdong Hospital of Guangxi Medical University, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Guangxi Collaborative Innovation Center for Biomedicine, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Life Sciences Institute, Guangxi Medical University, 530021, Nanning, China;Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Guangxi Collaborative Innovation Center for Biomedicine, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Orthopaedics, Langdong Hospital of Guangxi Medical University, The First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, China;Institute of Materials Research and Engineering (IMRE), A*STAR, 2 Fusionopolis Way, #08-03, 138634, Innovis, Singapore;

关键词: Osteoarthritis;    pH-responsive;    Metal–organic frameworks;    Protocatechuic acid;   

DOI  :  10.1186/s12951-020-00694-3

来源: Springer

【 摘 要 】

Drug therapy of osteoarthritis (OA) is limited by the short retention and lacking of stimulus-responsiveness after intra-articular (IA) injection. The weak acid microenvironment in joint provides a potential trigger for controlled drug release systems in the treatment of OA. Herein, we developed an pH-responsive metal − organic frameworks (MOFs) system modified by hyaluronic acid (HA) and loaded with an anti-inflammatory protocatechuic acid (PCA), designated as MOF@HA@PCA, for the therapy of OA. Results demonstrated that MOF@HA@PCA could smartly respond to acidic conditions in OA microenvironment and gradually release PCA, which could remarkably reduce synovial inflammation in both IL-1β induced chondrocytes and the OA joints. MOF@HA@PCA also down-regulated the expression of inflammatory markers of OA and promoted the expression of cartilage-specific makers. This work may provide a new insight for the design of efficient nanoprobes for precision theranostics of OA.

【 授权许可】

CC BY