Clinical and Translational Allergy | |
Unravelling the expression of interleukin-9 in chronic rhinosinusitis: A possible role for Staphylococcus aureus | |
Gabriele Holtappels1  Tim Delemarre1  Natalie De Ruyck1  Elien Gevaert1  Claus Bachert2  | |
[1] Department of Head & Skin, Upper Airways Research Laboratory, Faculty of Medicine, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium;Department of Head & Skin, Upper Airways Research Laboratory, Faculty of Medicine, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium;Division of ENT Diseases, CLINTEC, Karolinska Institute, Stockholm, Sweden;International Airway Research Center, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China; | |
关键词: Chronic rhinosinusitis with nasal polyps; Interleukin-9; Staphylococcus aureus; | |
DOI : 10.1186/s13601-020-00348-5 | |
来源: Springer | |
【 摘 要 】
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a Th2 biased inflammation, associated with nasal colonization of Staphylococcus (S.) aureus. Interleukin (IL)-9 is a pro-inflammatory Th2 cytokine with a pivotal role in asthma, allergy and chronic obstructive pulmonary disease (COPD), but is less studied in CRSwNP. We aimed to characterize the expression and cellular source of IL-9 and examined S. aureus as potential local trigger in CRSwNP. We showed increased numbers of interleukin-9 producing neutrophils and mononuclear cells in the tissue of CRSwNP patients. This interleukin-9 production was stimulated by S. aureus and its enterotoxin B in vitro. These findings underline the contribution of S. aureus and define IL-9 as another relevant cytokine in type 2 CRSwNP.
【 授权许可】
CC BY
【 预 览 】
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