Unravelling the expression of interleukin-9 in chronic rhinosinusitis: A possible role for Staphylococcus aureus

Clinical and Translational Allergy

Gabriele Holtappels¹  Tim Delemarre¹  Natalie De Ruyck¹  Elien Gevaert¹  Claus Bachert² 

[1] Department of Head & Skin, Upper Airways Research Laboratory, Faculty of Medicine, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium;Department of Head & Skin, Upper Airways Research Laboratory, Faculty of Medicine, Ghent University, C. Heymanslaan 10, 9000, Ghent, Belgium;Division of ENT Diseases, CLINTEC, Karolinska Institute, Stockholm, Sweden;International Airway Research Center, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China;

关键词: Chronic rhinosinusitis with nasal polyps;    Interleukin-9;    Staphylococcus aureus;   

DOI  :  10.1186/s13601-020-00348-5

来源: Springer

【 摘 要 】

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a Th2 biased inflammation, associated with nasal colonization of Staphylococcus (S.) aureus. Interleukin (IL)-9 is a pro-inflammatory Th2 cytokine with a pivotal role in asthma, allergy and chronic obstructive pulmonary disease (COPD), but is less studied in CRSwNP. We aimed to characterize the expression and cellular source of IL-9 and examined S. aureus as potential local trigger in CRSwNP. We showed increased numbers of interleukin-9 producing neutrophils and mononuclear cells in the tissue of CRSwNP patients. This interleukin-9 production was stimulated by S. aureus and its enterotoxin B in vitro. These findings underline the contribution of S. aureus and define IL-9 as another relevant cytokine in type 2 CRSwNP.

【 授权许可】

CC BY