Prevalence and factors associated with neonatal hypoglycemia in Northern Uganda: a community-based cross-sectional study

Tropical Medicine and Health

Thorkild Tylleskar¹  Victoria Nankabirwa²  Vincentina Achora³  James K. Tumwine⁴  Sarah Kiguli⁴  Thereza Piloya⁴  Grace Ndeezi⁴  Beatrice Odongkara⁵  Charles Batte⁶  James Ditai⁷  David Mukunya⁸ 

[1] Center for Intervention Science in Maternal and Child Health (CISMAC), Center for International Health, University of Bergen, Bergen, Norway;Center for Intervention Science in Maternal and Child Health (CISMAC), Center for International Health, University of Bergen, Bergen, Norway;Department of Epidemiology and Biostatistics, School of Public Health, Makerere University, Kampala, Uganda;Department of Obstetrics and Gynecology, University of Gulu, Gulu, Uganda;Department of Pediatrics and Child Health, Makerere University, Kampala, Uganda;Department of Pediatrics, University of Gulu, Gulu, Uganda;Center for International Health, University of Bergen, Bergen, Norway;Lung Institute, Makerere University, Kampala, Uganda;Sanyu Africa Research Institute, Mbale, Uganda;Sanyu Africa Research Institute, Mbale, Uganda;Center for Intervention Science in Maternal and Child Health (CISMAC), Center for International Health, University of Bergen, Bergen, Norway;Busitema University Faculty of Health Sciences, Mbale, Uganda;

关键词: Hypoglycemia;    Newborn care;    Breastfeeding;    Neonatal care;    Endocrinology;   

DOI  :  10.1186/s41182-020-00275-y

来源: Springer

【 摘 要 】

BackgroundNeonatal hypoglycemia is the most common endocrine abnormality in children, which is associated with increased morbidity and mortality. The burden and risk factors of neonatal hypoglycemia in rural communities in sub-Saharan Africa are unknown.ObjectiveTo determine the prevalence and risk factors for neonatal hypoglycemia in Lira District, Northern Uganda.MethodsThis was a community-based cross-sectional study, nested in a cluster randomized controlled trial designed to promote health facility births and newborn care practices in Lira District, Northern Uganda. This study recruited neonates born to mothers in the parent study. Random blood glucose was measured using an On Call® Plus glucometer (ACON Laboratories, Inc., 10125 Mesa Road, San Diego, CA, USA). We defined hypoglycemia as a blood glucose of < 47 mg/dl. To determine the factors associated with neonatal hypoglycemia, a multivariable linear regression mixed-effects model was used.ResultsWe examined 1416 participants of mean age 3.1 days (standard deviation (SD) 2.1) and mean weight of 3.2 kg (SD 0.5). The mean neonatal blood glucose level was 81.6 mg/dl (SD 16.8). The prevalence of a blood glucose concentration of < 47 mg/dl was 2.2% (31/1416): 95% CI 1.2%, 3.9%. The risk factors for neonatal hypoglycemia were delayed breastfeeding initiation [adjusted mean difference, − 2.6; 95% CI, − 4.4, − 0.79] and child age of 3 days or less [adjusted mean, − 12.2; 95% CI, − 14.0, − 10.4].ConclusionThe incidence of neonatal hypoglycemia was low in this community and was predicted by delay in initiating breastfeeding and a child age of 3 days or less. We therefore suggest targeted screening and management of neonatal hypoglycemia among neonates before 3 days of age and those who are delayed in the onset of breastfeeding.

【 授权许可】

CC BY