Research and application of single-cell sequencing in tumor heterogeneity and drug resistance of circulating tumor cells

Biomarker Research

Shou-yan Xiang¹  Chang-feng Man¹  Dan-dan Gong¹  Zhe Dai¹  Yu Fan¹  Xu-yu Gu¹ 

[1] Cancer Institution, Affiliated People’s Hospital of Jiangsu University, No.8 Dianli Road, 212002, Zhenjiang, Jiangsu Province, People’s Republic of China;

关键词: Tumor heterogeneity;    Circulating tumor cells;    Drug resistance;    Single-cell sequencing;   

DOI  :  10.1186/s40364-020-00240-1

来源: Springer

【 摘 要 】

Malignant tumor is a largely harmful disease worldwide. The cure rate of malignant tumors increases with the continuous discovery of anti-tumor drugs and the optimisation of chemotherapy options. However, drug resistance of tumor cells remains a massive obstacle in the treatment of anti-tumor drugs. The heterogeneity of malignant tumors makes studying it further difficult for us. In recent years, using single-cell sequencing technology to study and analyse circulating tumor cells can avoid the interference of tumor heterogeneity and provide a new perspective for us to understand tumor drug resistance.

【 授权许可】

CC BY