Hyperlipidemia and mortality associated with diabetes mellitus co-existence in Chinese peritoneal dialysis patients

Lipids in Health and Disease

Qian Zhou¹  Niansong Wang²  Xianfeng Wu²  Xiaoran Feng³  Xiaoyang Wang⁴  Fen Fen Peng⁵  Xin Wei⁶  Yueqiang Wen⁷ 

[1] Department of Medical Statistics, Clinical Trials Unit, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;Department of Nephrology, Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University, No.600, Yi Shan Road, Shanghai, China;Department of Nephrology, Jiujiang No. 1 People’s Hospital, Jiujiang, China;Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Department of Nephrology, Zhujiang Hospital of Southern Medical University, Guangzhou, China;Department of Nephrology, the First Affiliated Hospital of Nanchang University, Nanchang, China;Department of Nephrology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;

关键词: Diabetes mellitus;    Hyperlipidemia;    Mortality;    Peritoneal dialysis;    Prognosis;    Follow-up;    Long-term survival;   

DOI  :  10.1186/s12944-020-01405-5

来源: Springer

【 摘 要 】

BackgroundTo evaluate associations between diabetes mellitus (DM) coexisting with hyperlipidemia and mortality in peritoneal dialysis (PD) patients.MethodsThis was a retrospective cohort study with 2939 incident PD patients in China from January 2005 to December 2018. Associations between the DM coexisting with hyperlipidemia and mortality were evaluated using the Cox regression.ResultsOf 2939 patients, with a median age of 50.0 years, 519 (17.7%) died during the median of 35.1 months. DM coexisting with hyperlipidemia, DM, and hyperlipidemia were associated with 1.93 (95% CI 1.45 to 2.56), 1.86 (95% CI 1.49 to 2.32), and 0.90 (95% CI 0.66 to 1.24)-time higher risk of all-cause mortality, compared with without DM and hyperlipidemia, respectively (P for trend < 0.001). Subgroup analyses showed a similar pattern. Among DM patients, hyperlipidemia was as a high risk of mortality as non-hyperlipidemia (hazard ratio 1.02, 95%CI 0.73 to 1.43) during the overall follow-up period, but from 48-month follow-up onwards, hyperlipidemia patients had 3.60 (95%CI 1.62 to 8.01)-fold higher risk of all-cause mortality than those non-hyperlipidemia (P interaction = 1.000).ConclusionsPD patients with DM coexisting with hyperlipidemia were at the highest risk of all-cause mortality, followed by DM patients and hyperlipidemia patients, and hyperlipidemia may have an adverse effect on long-term survival in DM patients.

【 授权许可】

CC BY