Extracellular vesicles as potential biomarkers and therapeutic approaches in autoimmune diseases

Journal of Translational Medicine

Hui Yang¹  Xiang Wang¹  Kaihui Wu¹  Qin Liu¹  Maomao Zhao¹  Wenmei Wang¹  Kaiyuan Xu¹  Liu Liu¹ 

[1] Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, China;

关键词: Autoimmunity;    Biomarker;    Therapy;    Extracellular vesicle;    Exosomes;    MicroRNA;   

DOI  :  10.1186/s12967-020-02609-0

来源: Springer

【 摘 要 】

Extracellular vesicles are heterogeneous populations of naturally occurring secreted small vesicles. EVs function as signaling platforms to facilitate intracellular communication, which indicates the physiological or pathophysiological conditions of cells or tissues. Considering that EVs can be isolated from most body fluids and that molecular constituents could be reprogrammed according to the physiological status of the secreting cells, EVs are regarded as novel diagnostic and prognostic biomarkers for many diseases. The ability to protect encapsulated molecules from degradation in body fluids suggests the potential of EVs as biological medicines or drug delivery systems. This article focuses on the EV-associated biomarkers and therapeutic approaches in autoimmune diseases.

【 授权许可】

CC BY