Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease

Journal of Nanobiotechnology

Jie Zhu¹  Dong-qun Liu¹  Wei-wei Zhou¹  Shuai Lu¹  Xiao-lin Yu¹  Rui-tian Liu¹  Xiao-ge Liu²  Lun Zhang²  Ya-ru Huang² 

[1] State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China;State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190, Beijing, China;School of Chemical Engineering, University of Chinese Academy of Sciences, 100049, Beijing, China;

关键词: Alzheimer’s disease;    β-Amyloid;    Oligomer;    Class A scavenger receptor;    Therapy;   

DOI  :  10.1186/s12951-020-00723-1

来源: Springer

【 摘 要 】

BackgroundAlzheimer’s disease (AD) is a progressive neurodegenerative disorder. No disease-modifying strategy to prevent or delay AD progression currently exists. Aβ oligomers (AβOs), rather than monomers or fibrils, are considered as the primary neurotoxic species. Therapeutic approaches that direct against AβOs and promote Aβ clearance may have great value for AD treatment.ResultsWe here reported a multifunctional superparamagnetic iron oxide nanoparticle conjugated with Aβ oligomer-specific scFv antibody W20 and class A scavenger receptor activator XD4 (W20/XD4-SPIONs). Besides the diagnostic value, W20/XD4-SPIONs retained the anti-Aβ properties of W20 and XD4 by inhibiting Aβ aggregation, attenuating AβO-induced cytotoxicity and increasing microglial phagocytosis of Aβ. When applied to APP/PS1 mice, W20/XD4-SPIONs significantly rescued cognitive deficits and alleviated neuropathology of AD mice.ConclusionThese results suggest that W20/XD4-SPIONs show therapeutic benefits for AD. In combination with the early diagnostic property, W20/XD4-SPIONs present as a promising agent for early-stage AD diagnosis and intervention.

【 授权许可】

CC BY