PIWI-interacting RNAs and PIWI proteins in glioma: molecular pathogenesis and role as biomarkers

Cell Communication and Signaling

Mohammad Ali Pourattar¹  Mohammad Behnam²  Michael R. Hamblin³  Omid Reza Tamtaji⁴  Zatollah Asemi⁴  Hamed Mirzaei⁴  Maryam Mahjoubin-Tehran⁵ 

[1] Department of Radiobiology, Iran University of Medical Sciences, Tehran, Iran;Halal Research Center of IRI, FDA, Tehran, Iran;Laser Research Centre, Faculty of Health Science, University of Johannesburg, 2028, Doornfontein, South Africa;Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran;Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran;Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;

关键词: piRNAs;    PIWI protein;    Glioma;    Apoptosis;    Migration;    Invasion;   

DOI  :  10.1186/s12964-020-00657-z

来源: Springer

【 摘 要 】

Glioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI proteins are involved in tumorigenesis by epigenetic mechanisms. Hence, it seems that piRNAs and PIWI proteins may be potential prognostic, diagnostic or therapeutic biomarkers in the treatment of glioma. Previous studies have demonstrated a relationship between piRNAs and PIWI proteins and some of the molecular and cellular pathways in glioma. Here, we summarize recent evidence and evaluate the molecular mechanisms by which piRNAs and PIWI proteins are involved in glioma.8hHV3morV5vbNe-g9YJTMiVideo abstract

【 授权许可】

CC BY