oposSOM-Browser: an interactive tool to explore omics data landscapes in health science

BMC Bioinformatics

Siras Hakobyan¹  Henry Loeffler-Wirth²  Jasmin Reikowski²  Hans Binder²  Jonas Wagner³ 

[1] Group of Bioinformatics, Institute of Molecular Biology, National Academy of Sciences, 7 Hasratyan str, 0014, Yerevan, Armenia;Interdisciplinary Centre for Bioinformatics, Leipzig University, Härtelstraße 16-18, 04107, Leipzig, Germany;LIFE, Leipzig Research Center for Civilization Diseases, Leipzig University, Philipp-Rosenthal-Straße 27, 04103, Leipzig, Germany;

关键词: Interactive data analysis;    Transcriptomics;    Results browser;   

DOI  :  10.1186/s12859-020-03806-w

来源: Springer

【 摘 要 】

BackgroundoposSOM is a comprehensive, machine learning based open-source data analysis software combining functionalities such as diversity analyses, biomarker selection, function mining, and visualization.ResultsThese functionalities are now available as interactive web-browser application for a broader user audience interested in extracting detailed information from high-throughput omics data sets pre-processed by oposSOM. It enables interactive browsing of single-gene and gene set profiles, of molecular ‘portrait landscapes’, of associated phenotype diversity, and signalling pathway activation patterns.ConclusionThe oposSOM-Browser makes available interactive data browsing for five transcriptome data sets of cancer (melanomas, B-cell lymphomas, gliomas) and of peripheral blood (sepsis and healthy individuals) at www.izbi.uni-leipzig.de/opossom-browser.

【 授权许可】

CC BY