Migraine and sleep disorders: a systematic review

The Journal of Headache and Pain

Lucas Hendrik Overeem¹  Cindy Tiseo²  Simona Sacco²  Paolo Martelletti³  Serena Piroso⁴  Irina Anna Hubalek⁵  Alexander Tkachev⁶  Tamara Filimonova⁷  Annalisa Gai⁸  Alessandro Vacca⁸  Tatyana Glazyrina⁹  Anton Felbush^1,10  Yelena Marchenko^1,11 

[1] Charité – Universitätsmedizin Berlin Charité Centrum Neurologie, Neurochirurgie und Psychiatrie CC, Berlin, Germany;Department of Applied Clinical Sciences and Biotechnology, University of L’Aquila, L’Aquila, Italy;Regional Referral Headache Centre, S.S. Filippo e Nicola Hospital, Avezzano, L’Aquila, Italy;Department of Clinical and Molecular Medicine, Sapienza University of Rome, Roma, Italy;Regional Referral Headache Centre, Sant’Andrea Hospital, Rome, Italy;Department of Human Neurosciences, Sapienza University of Rome, Roma, Italy;Department of Neurology, Headache Center, Charité University Medicine Berlin, Berlin, Germany;Department of Neurology, Neurosurgery, medical genetics, I.M. Sechenov First Moscow State Medical University, Moscow, Russia;Federal State Budget Educational Institution of Higher Education “Academician Ye. A. Vagner Perm State Medical University” of the Ministry of Healthcare of the Russian Federation, Perm, Russia;Headache Center, Department of Neuroscience “Rita Levi Montalcini”, University of Torino, Torino, Italy;LLC Stomat Business Company, Moscow, Russia;Pain Treatment Center, OOO “Vertebra”, Samara City, Russia;V. A. Almazov National Medical Research Centre, Saint-Petersburg, Russia;

关键词: Headache;    Migraine;    Sleep disorders;    Insomnia;    Narcolepsy;    Restless leg syndrome;    Sleep apnea;    Periodic limb movement disorder;    Circadian rhythm sleep-wake disorders;    Parasomnias;   

DOI  :  10.1186/s10194-020-01192-5

来源: Springer

【 摘 要 】

Migraine and sleep disorders are common and often burdensome chronic conditions with a high prevalence in the general population, and with considerable socio-economic impact and costs.The existence of a relationship between migraine and sleep disorders has been recognized from centuries by clinicians and epidemiological studies. Nevertheless, the exact nature of this association, the underlying mechanisms and interactions are complex and not completely understood. Recent biochemical and functional imaging studies identified central nervous system structures and neurotransmitters involved in the pathophysiology of migraine and also important for the regulation of normal sleep architecture, suggesting a possible causative role, in the pathogenesis of both disorders, of a dysregulation in these common nervous system pathways.This systematic review summarizes the existing data on migraine and sleep disorders with the aim to evaluate the existence of a causal relationship and to assess the presence of influencing factors. The identification of specific sleep disorders associated with migraine should induce clinicians to systematically assess their presence in migraine patients and to adopt combined treatment strategies.

【 授权许可】

CC BY