Anti-COVID-19 drug screening: Frontier concepts and core technologies

Chinese Medicine

Chang Liu¹  Lin Yang¹  Hua Luo¹  Dechao Tan¹  Hua Yu¹  Ling Qiu¹  Yan Gao¹  Mingming Zhao¹ 

[1] Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Room 8008, Building N22, Avenida da Universidade, Taipa, Macao SAR, China;

关键词: COVID-19;    Disease model;    Core technology;    Traditional Chinese medicine;   

DOI  :  10.1186/s13020-020-00393-z

来源: Springer

【 摘 要 】

The outbreak of COVID-19 has recently evolved into a global pandemic. Up to July 2020, almost every country has confirmed COVID-19 cases reported worldwide. Many leading experts have predicted that the epidemic will persist for relatively a long period of time. Thus far, there have been no remedies proven effective against the disease. As the nation where COVID-19 broke out first, China has adopted a combination of traditional Chinese medicine and western medicine to fight against the disease, and has achieved significant clinical result. Up to now, the COVID-19 pandemic has been effectively controlled in China. However, the rest of the world (except for a limited number of countries and regions) is still in deep water. This paper thoroughly summarizes interdisciplinary notions and techniques, including disease model, biochip, network pharmacology, and molecular docking technology, etc., providing a reference for researchers in the screening of drugs for COVID-19 prevention and treatment. These methodologies may facilitate researchers to screen out more potential drugs for treating COVID-19 pneumonia and to tackle this global crisis.

【 授权许可】

CC BY