The changes of corneal biomechanical properties with long-term treatment of prostaglandin analogue measured by Corvis ST

BMC Ophthalmology

Na Wu¹  Yuhong Chen¹  Yaping Yang¹  Xinghuai Sun² 

[1] Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 200031, Shanghai, China;NHC Key Laboratory of Myopia (Fudan University); Key Laboratoy of Myopia, Chinese Academy of Medical Sciences, 200031, Shanghai, China;Shanghai Key Laboratoy of Visual Impairment and Restoration, 200031, Shanghai, China;Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 200031, Shanghai, China;NHC Key Laboratory of Myopia (Fudan University); Key Laboratoy of Myopia, Chinese Academy of Medical Sciences, 200031, Shanghai, China;Shanghai Key Laboratoy of Visual Impairment and Restoration, 200031, Shanghai, China;State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, 200032, Shanghai, China;

关键词: Prostaglandin analogue;    Corneal biomechanical properties;    Glaucoma;    Corvis ST;   

DOI  :  10.1186/s12886-020-01693-6

来源: Springer

【 摘 要 】

BackgroundTo investigate the corneal biomechanical changes in primary open angle glaucoma (POAG) patients treated with long-term prostaglandin analogue (PGA).MethodsOne hundred eleven newly diagnosed POAG patients, including 43 high tension glaucoma (HTG) and 68 normal tension glaucoma (NTG), were measured by Corvis ST to obtain intraocular pressure (IOP), central corneal thickness (CCT) and corneal biomechanical parameters at baseline and at each follow-up visit after initiation of PGA treatment. The follow-up measurements were analyzed by the generalized estimate equation model with an exchangeable correlation structure. Restricted cubic spline was employed to estimate the dose–response relation between follow-up time and corneal biomechanics.ResultsThe mean follow-up time was 10.3 ± 7.02 months. Deformation amplitude (β = -0.0015, P = 0.016), the first applanation velocity (AV1, β = -0.0004, P = 0.00058) decreased and the first applanation time (AT1, β = 0.0089, P < 0.000001) increased statistically significantly with PGA therapy over time after adjusting for age, gender, axial length, corneal curvature, IOP and CCT. In addition, AT1 was lower (7.2950 ± 0.2707 in NTG and 7.5889 ± 0.2873 in HTG, P = 0.00011) and AV1 was greater (0.1478 ± 0.0187 in NTG and 0.1314 ± 0.0191 in HTG, P = 0.00002) in NTG than in HTG after adjusting for confounding factors.ConclusionsChronic use of PGA probably influences the corneal biomechanical properties directly, which is to make cornea less deformable. Besides, corneas in NTG tended to be more deformable compared to those in HTG with long-term treatment of PGA.

【 授权许可】

CC BY