Mitomycin-C in dacryocystorhinostomy: From experimentation to implementation and the road ahead: A review

Indian Journal of Ophthalmology

关键词: Advanced glaucoma;    optical coherence tomography;    reproducibility;    retinal nerve fiber layer thickness;    spectral domain;    Ophthalmology;    residents;    surgical training;    survey;    Cytokine;    diabetic macular edema;    optical coherence tomography;    Macular GHPC;    pulse cyclophosphamide;    serpiginous choroidopathy;    Contact lens;    Corvis ST;    Confocal microscopy;    meibomian gland;    meibomian gland microenvironment;    papillary formation;    vernal keratoconjunctivitis;    Eye;    intra-arterial chemotherapy;    retinoblastoma;    tumor;    Dacryocystorhinostomy;    intubation;    lacrimal surgery;    mitomycin-C;    nasolacrimal duct obstruction;    primary acquired nasolacrimal duct obstruction;   

DOI  :  10.4103/0301-4738.158082

来源: DOAJ

【 摘 要 】

Dacryocystorhinostomy (DCR) is the procedure of choice in patients with epiphora due to primary acquired nasolacrimal duct obstruction. The evolution of surgical tools, fiber-optic endoscopes, effective anesthesia techniques, and the adjunct use of antimetabolites intraoperatively; namely mitomycin-C (MMC) have significantly contributed to the advancement of DCR surgery. MMC is a systemic chemotherapeutic agent derived from Streptomyces caespitosus that inhibits the synthesis of DNA, cellular RNA, and protein by inhibiting the synthesis of collagen by fibroblasts. Even the cellular changes in the human nasal mucosal fibroblasts induced by MMC at an ultrastructural level have been documented. There, however, seems to be a lack of consensus regarding MMC: The dosage, the route of delivery/application, the time of exposure and subsequently what role each of these variables plays in the final outcome of the surgery. In this review, an attempt is made to objectively examine all the evidence regarding the role of MMC in DCR. MMC appears to improve the success rate of DCR.

【 授权许可】

Unknown