Single-Atom Cobalt-Based Electrochemical Biomimetic Uric Acid Sensor with Wide Linear Range and Ultralow Detection Limit

Nano-Micro Letters

Qianghai Rao¹  Hong Bin Yang¹  Fang Xin Hu¹  Yuhang Liu¹  Tao Hu¹  Chunxian Guo¹  Chang Ming Li²  Shihong Chen³  Fangyin Dai⁴  Dongping Wang⁵ 

[1] Institute of Materials Science and Devices, Suzhou University of Science and Technology, 215009, Suzhou, People’s Republic of China;Institute of Materials Science and Devices, Suzhou University of Science and Technology, 215009, Suzhou, People’s Republic of China;Institute for Advanced Cross-field Science and College of Life Science, Qingdao University, 200671, Qingdao, People’s Republic of China;Institute for Clean Energy and Advanced Materials, School of Materials and Energy, Southwest University, 400715, Chongqing, People’s Republic of China;School of Chemistry and Chemical Engineering, Southwest University, 400715, Chongqing, People’s Republic of China;State Key Laboratory of Silkworm Genome Biology, College of Biotechnology, Southwest University, 400715, Chongqing, People’s Republic of China;Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, 215163, Suzhou, People’s Republic of China;

关键词: Single-atom cobalt;    Nanozyme;    Biocatalysis;    Uric acid;    Molecular interaction;   

DOI  :  10.1007/s40820-020-00536-9

来源: Springer

【 摘 要 】

tsA single-atom catalyst of A–Co–NG is explored for electrochemical uric acid (UA) detection for the first time and realize practical UA monitoring in serum samples.The A–Co–NG sensor demonstrates high performance for UA detection with a wide detection range from 0.4 to 41950 μM and an extremely low detection limit of 33.3 nM.Combination of experimental and theoretical calculation discovers mechanism for the UA oxidation on the single-atom catalyst.

【 授权许可】

CC BY