The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases

Microbiome

Jun Wang¹  Ting-yu Sun²  Yu-ming Chen²  Chu-wen Ling²  Jian Yang³  Wanglong Gou⁴  Menglei Shuai⁴  Zelei Miao⁴  Fengzhe Xu⁴  Yuanqing Fu⁵  Zengliang Jiang⁵  Ju-Sheng Zheng⁶ 

[1] CAS Key Laboratory for Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China;Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China;Institute for Molecular Bioscience, The University of Queensland, QLD, Brisbane, Australia;Institute for Advanced Research, Wenzhou Medical University, 325027, Wenzhou, Zhejiang, China;Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China;Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China;Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China;Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China;Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China;MRC Epidemiology Unit, University of Cambridge, Cambridge, UK;

关键词: Gut microbiome;    Host genetics;    Bidirectional Mendelian randomization analyses;    Disease-microbiome features;   

DOI  :  10.1186/s40168-020-00923-9

来源: Springer

【 摘 要 】

BackgroundInterest in the interplay between host genetics and the gut microbiome in complex human diseases is increasing, with prior evidence mainly being derived from animal models. In addition, the shared and distinct microbiome features among complex human diseases remain largely unclear.ResultsThis analysis was based on a Chinese population with 1475 participants. We estimated the SNP-based heritability, which suggested that Desulfovibrionaceae and Odoribacter had significant heritability estimates (0.456 and 0.476, respectively). We performed a microbiome genome-wide association study to identify host genetic variants associated with the gut microbiome. We then conducted bidirectional Mendelian randomization analyses to examine the potential causal associations between the gut microbiome and complex human diseases. We found that Saccharibacteria could potentially decrease the concentration of serum creatinine and increase the estimated glomerular filtration rate. On the other hand, atrial fibrillation, chronic kidney disease and prostate cancer, as predicted by host genetics, had potential causal effects on the abundance of some specific gut microbiota. For example, atrial fibrillation increased the abundance of Burkholderiales and Alcaligenaceae and decreased the abundance of Lachnobacterium, Bacteroides coprophilus, Barnesiellaceae, an undefined genus in the family Veillonellaceae and Mitsuokella. Further disease-microbiome feature analysis suggested that systemic lupus erythematosus and chronic myeloid leukaemia shared common gut microbiome features.ConclusionsThese results suggest that different complex human diseases share common and distinct gut microbiome features, which may help reshape our understanding of disease aetiology in humans.D8HH2e9efBg_dUkabV_mryVideo Abstract

【 授权许可】

CC BY